To elucidate the antigenic drift and evolution of h9n2 subtype avian influenza viruses ( aivs ) , five isolates from the north of henan province during 1998 - 2002 were compared and analysed by cross - hemagglutinin inhibition test ( hi ) , cross - virus neutralization test ( vn ) in the chicken embryo and chicken embryo primary kidney cell ( cek ) and cross protection against challenge infection test 為了探討h _ 9n _ 2亞型禽流感病毒的抗原性有否發(fā)生漂移,本研究從生物學(xué)角度和ha基因分子水平上對(duì)1998 ? 2002年間在河南省豫北地區(qū)分離到的5株h _ 9n _ 2亞型禽流感病毒的抗原性變化進(jìn)行了比較和分析。
To answer this question , a bispecific , trifunctional antibody constructs which can not only target block virus incorporated rca , but also can induce complement activation by it ' s fc fragment were designed and constructed and iv the role of this kind of bispecific antibody in virus neutralization was studied . 1 . to test our idea , human immunodeficient virus ( hiv ) and enveloped extracellular virus ( eev ) of vaccinia virus ( vv ) were selected in our study because of their complex immune evasion stratiges , their threaten to humans , and because both these two kinds of virus can escape complement attack by incorporating host rca into their envelope 以嚴(yán)重危害人類健康,且具有復(fù)雜免疫逃避機(jī)制的有包膜的hiv病毒及痘苗病毒的eev病毒為研究對(duì)象,首先對(duì)它們逃避補(bǔ)體攻擊的現(xiàn)象進(jìn)行了驗(yàn)證,探討了宿主膜補(bǔ)體調(diào)節(jié)蛋白cd55 、 cd59與hiv病毒及eev病毒免疫逃避的關(guān)系,評(píng)價(jià)了病毒結(jié)合的這兩種補(bǔ)體調(diào)節(jié)蛋白作為本研究提出的,通過消除病毒逃避補(bǔ)體攻擊的機(jī)制來恢復(fù)病毒對(duì)補(bǔ)體攻擊的敏感性,提高補(bǔ)體抗病毒效率這一抗病毒策略的靶點(diǎn)的可能性。